All About Beer had a great article this month,Touring Prague: Understanding Czech Beer in Five Easy Stops.
Aside from Lokál, which I have not been to yet, I agree with their selections. U Fleků and Klášterní Pivovar Strahov are two of my favorite places... old faithfuls if you will. I'd say if you'll be visiting Prague, these 5 stops are a definite must. Beer tour, anyone?
I've posted about Pivovar Strahov before and you can read it here, a well as Zlý Časy, which you will find here.
I think we can all agree that Homer Simpson says it best...