Karlin is a great neighborhood in Prague... one that many tourists probably don't get to see unless they're curious and like to explore. I, for one, prefer to head off the beaten path and venture into neighborhoods that aren't filled with souvenir shops and folks shoving pamphlets into my face of tours they offer. If you don't venture out, you miss experiencing what life is like for those who live in the city... what the residential neighborhoods consist of... and what makes them special.
The New York Times had a good article on Karlin... a neighborhood in Prague 8
Another great article that will tell make you want to visit Karlin is